A well-built clinial/research question includes 4 or more components:
P = patient/population
I = intervention
C = comparison or "gold standard"
O = outcome(s)
(T) = timeframe, type of question
Tip: When searching, pick out the 2 or 3 most significant elements; forcing all pieces of the question may not yield useful results.
Example PICO Question:
Among children receiving general anesthesia, what are the risk factors for adverse perioperative respiratory events?